Genetics of immunity deficiency syndromes.

COMMENTARY: GENETICS OF IMMUNITY The Genetics of Immunity

DEFENSE against infection is increasingly recognized to have a complex determination, shaped by the contributions of multiple genes and a multitude of environmental factors. While we may conventionally imagine defense against infection to be determined primarily by the activity of the host immune system, recent studies have established diverse biological mechanisms for regulating defense. The g...

Genetics of the polymicrogyria syndromes.

Polymicrogyria is a relatively common malformation of cortical development, characterised by multiple small gyri with abnormal cortical lamination. The different forms of polymicrogyria encompass a wide range of clinical, aetiological, and histological findings. Advances in imaging have improved the diagnosis and classification of the condition. The molecular basis of polymicrogyria is beginnin...

The Genetics of Immunity

In this commentary, Brian P. Lazzaro and David S. Schneider examine the topic of the Genetics of Immunity as explored in this month's issues of GENETICS and G3: Genes|Genomes|Genetics. These inaugural articles are part of a joint Genetics of Immunity collection (ongoing) in the GSA journals.

Creatine Deficiency Syndromes

Genetics of inherited cardiocutaneous syndromes: a review

The life of a human being originates as a single cell which, under the influence of certain factors, divides sequentially into multiple cells that subsequently become committed to develop and differentiate into the different structures and organs. Alterations occurring early on in the development process may lead to fetal demise in utero. Conversely, abnormalities at later stages may result in ...